Oxygen level is a critical regulator of human b cell differentiation and igg class switch recombination

HIGHLIGHTS

• who: Jana Koers and collaborators from the University of Rennes, France have published the research work: Oxygen level is a critical regulator of human B cell differentiation and IgG class switch recombination, in the Journal: (JOURNAL)
• what: The authors systematically investigated the effect of atmospheric (21%), normoxic, tissue-associated (3%), and hypoxic (1%) pO2 on human B cell differentiation in the highly optimized system for human primary B cell culture. The authors show that different oxygen pressures distinctly regulate human naive B cell differentiation and class switch recombination. leads to generation of a GC response . . .
  

   

  

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