Oxyresveratrol and/or dapagliflozin attenuate doxorubicin-induced nephrotoxicity via modulation of ppar-γ/nrf-2/ho-1, nf-κb/tnf-α/keap-1, and bcl-2/caspase-3/atg-5 signaling pathways in rats

HIGHLIGHTS

• What: In comparison with the healthy control group, the study revealed that the kidney tissues in this investigation showed a considerable rise in MDA and N ­ O2- by 9.33 and 2.91 times, respectively, following the administration of DOX. The aim of this investigation was to assess any potential defenses against DOX-induced nephrotoxicity offered by ORES and/or DAPA, utilizing Vit. Consistent with other studies (Guo et_al 2013), this investigation showed that, relative to the control group, DOX significantly raised the renal gene_expression of NF-κB, as well as blood levels of IL-6 and . . .
  

   

  

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