HIGHLIGHTS
- who: Chung-Pu Wu and colleagues from the Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan have published the paper: P-glycoprotein Mediates Resistance to the Anaplastic Lymphoma Kinase Inhibitor Ensartinib in Cancer Cells, in the Journal: (JOURNAL)
- what: The authors investigated the interaction of ensartinib with (P-gp) and ABCG2 two ATP-binding cassette (ABC) multidrug efflux transporters that are commonly associated with the development of multidrug resistance in cancer cells. The authors report that ensartinib is a substrate of P-gp and provide evidence that this transporter plays . . .
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