HIGHLIGHTS
- who: Sudhakar Reddy Kalluri from the Technical University of Munich, Munich, Germany have published the research: P2R Inhibitors Prevent Antibody-Mediated Complement Activation in an Animal Model of Neuromyelitis Optica, in the Journal: (JOURNAL)
- what: The study demonstrates that P2R inhibitors can disrupt complement activation by direct interaction with IgG. Using a cell-based antibody-binding assay, size-exclusion chromatography (SEC), and circular dichroism (CD) spectroscopy of IgG molecules, the authors demonstrate that this is likely due to a concentration-dependent partial unfolding of IgG by P2R inhibitors, thus disrupting complement activation, needed for AQP4 . . .
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