P2x-gcamps as versatile tools for imaging extracellular atp signaling

HIGHLIGHTS

  • who: ATP and colleagues from the Institut Génomique Fonctionnelle, Université, Centre Scientifique, Institut Therapeutics, France have published the Article: P2X-GCaMPs as Versatile Tools for Imaging Extracellular ATP Signaling, in the Journal: (JOURNAL) of December/30,/2020
  • what: The authors report the development of biosensors based on the fusion of cation permeable receptors (P2X) to genetically encoded calcium sensors . The authors provide the proof of concept that these sensors can dynamically track release evoked by depolarization in mouse neurons or by extracellular hypotonicity. A genetically encoded version of this assay was developed (Pellegatti et_al . . .

     

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