P2y2 interstitial cell calcification and myofibroblastic activation

HIGHLIGHTS

  • who: CAVS and colleagues from the Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy have published the article: P2Y2 Interstitial Cell Calcification and Myofibroblastic Activation, in the Journal: Biomedicines 2022, 10, 457. of /2022/
  • what: The aim of this study was to evaluate the effects of P2Y2 (P2RY2) activation on fibro-calcific remodeling of Methods- the authors employed human primary isolated from leaflets treated with 2-thiouridine-50 -triphosphate (2ThioUTP 10 µM) an agonist of P2RY2. Despite the huge number of studies aimed at defining the molecular effectors of CAVS progression, they . . .

     

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