P35, the neuronal-specific activator of cyclin-dependent kinase 5 (cdk5) is degraded by the ubiquitin-proteasome pathway*

HIGHLIGHTS

• who: Gentry N. Patrick from the (UNIVERSITY) have published the paper: p35, the Neuronal-specific Activator of Cyclin-dependent Kinase 5 (Cdk5) Is Degraded by the Ubiquitin-Proteasome Pathway*, in the Journal: (JOURNAL) of June/10,/1998
• what: The authors show that p35, the activator of Cdk5, is a short-lived protein with a half-life (t1/2) of 20 to 30 min.

SUMMARY

Specific proteasome inhibitors such as lactacystin greatly stabilize p35 in_vivo. Ubiquitination of p35 can be readily demonstrated in_vitro and in_vivo. Together, these observations demonstrate that the p35 . . .

 



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