HIGHLIGHTS
SUMMARY
Loss of MT4‑MMP increases p38 MAPK signaling in basal VSMCs in_vitro, leading to their enhanced proliferation in response to PDGF‑BB. The authors first established an in_vitro model of VSMCs iso- lated from the aorta of young mice and stimulated them with the mitogen PDGF-BB4 to mimic the developmental context17. To determine if p38 MAPK activation in basal MT4-MMP-/- VSMCs may underlie their proliferation phenotype in response to PDGF-BB, the authors used the α/β p38 MAPK isoform inhibitor SB20358023. p38 MAPK inhibition abrogated the enhanced PDGF-BB-induced proliferation in MT4 . . .
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