HIGHLIGHTS
- who: Kealan McElhinney and collaborators from the UCD Clinical Research Centre, Mater Misericordiae University Hospital, R WY Dublin, Ireland have published the research: p53 and Myofibroblast Apoptosis in Organ Fibrosis, in the Journal: (JOURNAL)
- what: This study showed that p53 and p21 upregulation was associated with chronic DNA damage, cell-cycle arrest, and apoptosis in IPF tissues (compared to normal control)-this was quantified through immunohistochemistry and Terminal deoxynucleotidyl transferase dUTP nick end labelling assay . This study examined hypoxia-induced renal fibrosis in a human and rat renal tubular epithelial_cells and a mouse UUO model . . .
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