HIGHLIGHTS
- who: Lei Yong and colleagues from the Chongqing Medical University, China have published the research: p53 inhibits CTR1-mediated cisplatin absorption by suppressing SP1 nuclear translocation in osteosarcoma, in the Journal: (JOURNAL)
- what: To further explore the nuclear transfer of p53, the authors focused on the protein interacting with CTR1. This study investigated the association between p53 and cisplatin absorption in OS cells. What is different is that the work demonstrates that p53 works at the upper stream of SP1 in the regulation of cisplatin uptake, which constitutes the p53-SP1CTR1 axis.
- how . . .
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