HIGHLIGHTS
- who: Gai Yamashita from the (UNIVERSITY) have published the article: p53 regulates lysosomal membrane permeabilization as well as cytoprotective autophagy in response to DNA-damaging drugs, in the Journal: (JOURNAL) of 21/Dec/2022
- what: This study investigates the underlying molecular mechanism of p53dependent LMP and autophagy induction. This study demonstrated that BID induces LMP probably independent from the BAK/BAX because BID KD much strongly repressed LMP than BAX/BAK DKD. As this study reports tBID localization on isolated lysosomes, tBID may directly induce LMP. This study showed that p53 activation by DNA damage . . .
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