P73 is required for vessel integrity controlling endothelial junctional dynamics through angiomotin

HIGHLIGHTS

  • who: Laura Maeso-Alonso from the Instituto de Biomedicina y Departamento de Biologu00eda Molecular, Universidad de Leu00f3n, Leu00f3n, Spain have published the Article: p73 is required for vessel integrity controlling endothelial junctional dynamics through Angiomotin, in the Journal: (JOURNAL)
  • what: The authors propose a new model in which TAp73 acts as a vascular architect integrating transcriptional programs that will impinge with Angiomotin/YAP signaling to maintain junctional dynamics and integrity while balancing endothelial cell rearrangements in angiogenic vessels. The authors demonstrate p73 essential role in the maintenance of the endothelial junction dynamics and barrier integrity . . .

     

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