HIGHLIGHTS
SUMMARY
Over recent years, targeting the tumor microenvironment (TME) has emerged as a hot topic in tumor therapy and the TME determines the effectiveness of immunotherapy (Noguchi et_al, 2017; Wei et_al, 2019; Wu et_al, 2021). It has been demonstrated in many studies that lncRNA expression disorders are associated with a variety of cancers and these frequent aberrant expressions are closely related to tumorigenesis, development and metastasis (Ji et_al, 2021; Feng et_al, 2022). Related researches also find that lncRNA regulates drug resistance in multiple tumor types on top of its oncogenic function (Barik et_al, 2021; Zhou . . .
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