Pan-cancer analysis shows enrichment of macrophages, overexpression of checkpoint molecules, inhibitory cytokines, and immune exhaustion signatures in emt-high tumors

HIGHLIGHTS

• who: Jayesh Kumar Tiwari from the Center, United States Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology (Banaras Hindu University) have published the paper: Pan-Cancer Analysis Shows Enrichment of Macrophages, Overexpression of Checkpoint Molecules, Inhibitory Cytokines, and Immune Exhaustion Signatures in EMT-High Tumors, in the Journal: (JOURNAL)
• what: The authors analyzed 7,968 tumor samples representing 22 distinct cancer types from TCGA dataset . In the analysis , the authors noted mild enrichment of Tregs in EMT-low patients of PAAD and LUAD, but LUSC did not show any difference.
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