Pan-cancer landscape of aid-related mutations, composite mutations, and their potential role in the ici response

HIGHLIGHTS

  • who: Isaias Hernu00e1ndez-Verdin from the Published in partnership with The Hormel Institute, University of Minnesota have published the article: Pan-cancer landscape of AID-related mutations, composite mutations, and their potential role in the ICI response, in the Journal: (JOURNAL)
  • what: As the effect was tightly marked only in Ipi-Naive patients, the authors focused the subsequent analysis on only this group. The authors propose a model in which AID ICN has higher probabilities of being recognized by T-cells, triggering selective expression CXCL13, previously found to be a marker of antigen reactive CD8 . . .

     

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