HIGHLIGHTS
- who: Siavash Raigani from the Medical University of South Carolina, United States have published the article: Pan-caspase inhibition during normothermic machine perfusion of discarded livers mitigates ex situ innate immune responses, in the Journal: (JOURNAL)
- what: In this study of discarded livers subjected to NMP, livers with IHF were characterized by abundant apoptotic cell death, robust and sustained activation of innate immunity, and decreased activation of ER stress response pathways (autophagy) when compared to livers with AHF.
- how: The authors hypothesized that caspase inhibition would bolster cell survival and upregulate autophagy thereby . . .
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