HIGHLIGHTS
- who: Irene Miguel-Escalada from the Centre of Science and Technology, DrAiguader, Barcelona, Spain have published the article: Pancreas agenesis mutations disrupt a lead enhancer controlling a developmental enhancer cluster, in the Journal: (JOURNAL) of August/22,/2022
- what: Using stage-specific single-cell chromatin profiles, the authors show that PTF1A orchestrates an epigenetic endocrine differentiation program. Given that PTF1A has a direct impact on the chromatin states of endocrine regulatory_genes in early MPCs, the authors focused on essential endocrine regulatory loci in the subsequent "trunk" stage. This study shows that a non-coding element . . .
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