HIGHLIGHTS
- who: Yueming Long and collaborators from the Department of Chemistry, Wake Forest University, Winston-Salem, NC, USA have published the research work: Para-Substituted O-Benzyl Sulfohydroxamic Acid Derivatives as Redox-Triggered Nitroxyl (HNO) Sources, in the Journal: Molecules 2022, 5305 of /2022/
- what: The authors report a small library of derivatives (1a-d and 2a-c) of the HNO donor, Piloty's acid, that liberate HNO upon oxidation or reduction through a 1, 6 elimination mechanism.
- future: Investigation will be necessary to define the practicality of nitroreductase-triggered HNO donors but these . . .
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