HIGHLIGHTS
SUMMARY
In contrast to CD8+ T_cells, whose fraction stayed nearly unchanged between tumor and normal samples, the authors observed an over fivefold increase in CD4+ T_cells in the gastric tumor samples. To understand which T_cell subsets most differentially invaded the gastric TME, the authors reclustered the 12,905 C D4+ T_cells into eight subclusters which the authors then assigned to six T helper cell subtypes including regulatory (FOXP3, IL2RA), helper 17 (IL17A), naïve (CCR7), central memory (CM) (ANXA1, CCR7), effector memory (EM) (ANXA1, CCL5), and follicular T helper cells (CXCL13) (Fig 5a and S6a . . .
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