Parallel single-cell metabolic analysis and extracellular vesicle profiling reveal vulnerabilities with prognostic significance in acute myeloid leukemia

HIGHLIGHTS

• What: The authors show a potential noninvasive approach based on liquid ‘cell-extracellular vesicle` biopsy toward a redefined metabolic stratification in AML. Circulating CD34+CD38low/- stem/progenitor AML cells show a distinct metabolic profile with increased levels of GSH and mitochondrial potential (MITO) To minimize the impact of intratumoral heterogeneity, the study focused on the CD34+(CD38low/-) fractions, representing the most common immunophenotype in AML, for a more consistent and standardized approach. Next, the authors aimed to identify metabolic features using fresh whole blood associated with European LeukemiaNet (ELN) 2022 categories27. Specifically, the authors focused on the . . .
  

   

  

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