HIGHLIGHTS
- who: POSTER PRESENTATION and colleagues from the (UNIVERSITY) have published the research work: Parkin acts as a transcription factor modulating presenilin-1 and presenilin-2 promoter transactivations, in the Journal: (JOURNAL)
SUMMARY
Parkin is associated to autosomal recessive early-onset Parkinson's disease. Parkin acts as an E3-ubiquitin ligase involved in the proteasome-mediated degradation of various substrates. It has been suggested that pathogenic mutations of parkin, abolishing its ubiquitin-ligase activity, could explain the accumulation of proteins and lead to neuronal death by apoptosis. Besides this function, additional parkin-dependent cellular . . .
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