HIGHLIGHTS
SUMMARY
Parkin resides in the cytosol in an autoinhibited state and is recruited to mitochondria by binding pS65-Ub (Okatsu et al, 2015b). pS65-Ub binding partially displaces Parkin`s Ubl domain, which allows it to be phosphorylated by PINK1 (Gladkova et al, 2018). Many questions remain about the mechanisms of PINK1-Parkin-mediated mitochondrial quality_control in_vivo. The authors confirm that pS65-Ub is produced by Drosophila Pink1 in_vivo and can therefore be utilised to follow activation of the Pink1-parkin pathway and the downstream mechanisms of mitochondrial turnover. The authors identify exposure to the . . .
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