Parkinson-causing mutations in lrrk2 impair the physiological tetramerization of endogenous α-synuclein in human neurons

HIGHLIGHTS

• who: Luis Fonseca-Ornelas from the (UNIVERSITY) have published the research: Parkinson-causing mutations in LRRK2 impair the physiological tetramerization of endogenous u03b1-synuclein in human neurons, in the Journal: (JOURNAL)
• what: Mechanistically, the authors show that two distinct LRRK2 kinase inhibitors30,31 can reverse the u03b1Syn alterations in the G2019S and the R1441C neurons. The authors show here that the T:M ratio of u03b1Syn correlates quantitatively with its pSer129 phosphorylation: lower T:M ratios are associated with more monomer phosphorylation (Fig 6). All participants who provided samples for the generation of iPSC lines . . .
  

   

  

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