Parp14 promotes the warburg effect in hepatocellular carcinoma by inhibiting jnk1-dependent pkm2 phosphorylation and activation

HIGHLIGHTS

• who: Valeria Iansante from the Gastrointestinal and Liver Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, Department of Medical Oncology have published the research work: PARP14 promotes the Warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS of 10/08/2015
• what: In this study using loss-offunction studies in vitro and in vivo the authors show that the anti-apoptotic protein poly(ADP-ribose) polymerase (PARP)14 promotes aerobic glycolysis in human hepatocellular carcinoma (HCC) by maintaining low activity of the . . .
  

   

  

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