Parp3 negatively regulates immunoglobulin class switch recombination

HIGHLIGHTS

• who: Isabelle Robert and colleagues from the Supu00e9rieure de Biotechnologie de Strasbourg, FranceEditor: Nancy Maizels, University of Washington have published the Article: Parp3 Negatively Regulates Immunoglobulin Class Switch Recombination, in the Journal: (JOURNAL) of November/17,/2014
• what: The authors propose that plays a CSR-specific role by controlling AID levels at regions during CSR. The authors show that Poly(ADP)ribose polymerase 3 (Parp3) an enzyme recently implicated in DNA repair contributes to antibody diversification by regulating CSR without affecting SHM. The authors show that facilitates the repair of AID-induced DNA damage and . . .
  

   

  

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