HIGHLIGHTS
- who: (PTL and collaborators from the Lund University, Sweden United States have published the research work: Parthenolide induces rapid thiol oxidation that leads to ferroptosis in hepatocellular carcinoma cells, in the Journal: (JOURNAL)
- what: The authors demonstrate that not only does PTL result in a decrease in the level of GSH and elevation of ROS within cancer cells, but this depletion of GSH results in a downstream form of cell death known as ferroptosis. This study shows that thiol oxidation from PTL occurs very quickly, leading to early mitochondrial dysfunction and oxidative stress.
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