Partial fads2 gene knockout diverts lc-pufa biosynthesis via an alternative 8 pathway with an impact on the reproduction of female zebrafish (danio rerio)

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SUMMARY

    Long-chain polyunsaturated_fatty_acids (LC-PUFAs) are of high significance in healthy state maintenance and the reproduction success of virtually all vertebrates. In fast developing tissues in the early stages of life, the demand on LC-PUFAs is especially high; 2 of 13 correspondingly, the expression from genes encoding desaturases and some other genes of the LC-PUFA biosynthetic pathway is high. In the first and rate-limiting_step, FADS2 converts C18:2 ∆9,12 (LA) and the C18:3 ∆9,12,15 (ALA) into C18:3 ∆6,9,12 (γ-linoleic acid, GLA) and C18:4 . . .

     

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