HIGHLIGHTS
- who: Jesus J. Benito-Lopez and colleagues from the Yale University, United States have published the research work: Partners in crime: The feedback loop between metabolic reprogramming and immune checkpoints in the tumor microenvironment, in the Journal: (JOURNAL)
- what: The authors propose that, in addition to promoting immune evasion at the primary tumor, a high lactate production may facilitate the establishment of the premetastatic niche.
- future: Although changes in the concentrations of glucose and lactate have been shown to inhibit the effector mechanisms and change the phenotype of T_cells more studies are needed . . .
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