Pathogenetic mechanisms underlying spinocerebellar ataxia type 3 are altered in primary oligodendrocyte culture

HIGHLIGHTS

• who: Kristen H. Schuster and colleagues from the Department of Neurology, University of Michigan, Ann Arbor, MI, USA have published the paper: Pathogenetic Mechanisms Underlying Spinocerebellar Ataxia Type 3 Are Altered in Primary Oligodendrocyte Culture, in the Journal: Cells 2022, 11, 2615. of /2022/
• what: The authors used primary oligodendrocyte cultures to determine how known pathogenic SCA3 mechanisms affect this cell type. The authors characterize key protein changes of pathways known to be disrupted in SCA3 within the general oligodendrocyte population, including the ubiquitin-proteasome system and autophagy. The authors demonstrate both gain- and loss . . .
  

   

  

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