HIGHLIGHTS
- who: Mabel Minji Jung et al. from the Department University of Health, Madison, Wisconsin, USA have published the research: Pathogenic human variant that dislocates GATA2 zinc_fingers disrupts hematopoietic gene_expression and signaling networks Wisconsin Blood Cancer Research, in the Journal: (JOURNAL)
SUMMARY
Artificial zinc_finger proteins can be engineered with designer DNA binding specificities for experimental and therapeutic applications. Insertion of KTS residues between Wilms tumor 1 zinc_fingers via alternative splicing alters DNA binding specificity. Unlike sophisticated zinc_finger structure/function knowl- edge, the impact of spacer length and sequence and alterations thereof cannot be predicted . . .
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