HIGHLIGHTS
- who: Elena Fdez from the (CSIC), Granada, Spain State University have published the paper: Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement, in the Journal: (JOURNAL) of June/17,/2022
- what: The authors have investigated the mechanism by which pathogenic LRRK2 causes centrosomal cohesion deficits in cultured cells, and the authors report that the mechanism requires Rab10 and RILPL1 proteins and is due to interfering with the proper centrosomal localization of CDK5RAP2. The authors show here that the centrosomal cohesion deficits mediated by pathogenic LRRK2 depend on the GTP conformation and phosphorylation . . .
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