Pathogenic p62/sqstm1 mutations impair energy metabolism through limitation of mitochondrial substrates

HIGHLIGHTS

• who: Fernando Bartolome from the (UNIVERSITY) have published the research: Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates, in the Journal: (JOURNAL) of 30/03/2017
• what: In this work the role of p62 in energy metabolism was studied in fibroblasts from FTD patients carrying two independent pathogenic mutations in the p62 gene, and in a p62-knock-down (p62 KD) human dopaminergic neuroblastoma cell line (SH-SY5Y). The analysis of the FAD autofluorescence (Fig 3A) was used to generate the FAD redox index (Fig 3B and C) which was higher . . .
  

   

  

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