HIGHLIGHTS
- who: Yuechun Zhao from the (UNIVERSITY) have published the research: Pathogenic sphingosine 1-phosphate pathway in psoriasis: a critical review of its pathogenic significance and potential as a therapeutic target, in the Journal: (JOURNAL)
- what: S1P and its signaling play an important role in the pathogenesis of many autoimmune diseases, and it is intimately involved in psoriasis pathogenesis by inhibiting keratinocyte proliferation, regulating immune cell migration, and promoting dermal angiogenesis and repair in several ways.
- future: More topical agents targeting the S1P axis are in progress while refining the targeting of S1P receptor . . .
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