Pathogenic tau decreases nuclear tension in cultured neurons

HIGHLIGHTS

• who: January and collaborators from the University of Glasgow, United Kingdom have published the paper: Pathogenic tau decreases nuclear tension in cultured neurons, in the Journal: (JOURNAL)
• how: As a first step toward determining if the effects of pathogenic tau on nuclear structure alter nuclear tension the authors developed a BE(2)-C neuroblastoma cell model that features doxycyclineinducible expression of human tau carrying the frontotemporal dementia-associated mutation R406W (Hutton et_al 1998) (tauR406W).
• future: These results highlight the mechanosensing properties of the nucleus in neurons and lay the groundwork for future investigation . . .
  

   

  

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