Pathophysiology of mesangial expansion in diabetic nephropathy: mesangial structure, glomerular biomechanics, and biochemical signaling and regulation

HIGHLIGHTS

• who: Haryana Y. Thomas from the (UNIVERSITY) have published the research: Pathophysiology of mesangial expansion in diabetic nephropathy: mesangial structure, glomerular biomechanics, and biochemical signaling and regulation, in the Journal: (JOURNAL)
• what: The authors examine the structural and functional relationships in the mesangium between the mesangial cell, matrix, and GBM to show that the mesangial cell has functions important to the biomechanical homeostasis of the glomerulus.
• how: These results indicated that mesangial expansion is an important structural change even more so than the GBM thickening in the progression of diabetic nephropathy.
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