HIGHLIGHTS
- who: Benjamin Galet from the CNRS Sorbonne University, Paris, France have published the research: Patient-Derived Midbrain Organoids to Explore the Molecular Basis of Parkinson's Disease, in the Journal: (JOURNAL)
- what: The development of these protocols triggered a wave of characterization studies aiming at identifying altered phenotypes of 2D mDA cultures derived from patient hiPSCs carrying monogenic (PAKR2, PINK1, LRRK2, SNCA, GBA, and OPA1) or sporadic forms of the disease.
- future: In this regard future studies integrating large cohort GWAS data with patient stratification strategies may help identify molecular mechanisms driving PD . . .
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