Pax6 is expressed in pancreatic cancer and actively participates in cancer progression through activation of the met tyrosine kinase receptor gene*

HIGHLIGHTS

• who: Joseph B. Mascarenhas from the Joseph BMascarenhas, Kacey P. Young, Erica L. Littlejohn, Brian K. Yoo, Ravi Salgia, and Deborah Lang, From the Department of Medicine, University of Chicago, Chicago, Illinois , Tumors of the exocrine pancreas have a poor prognosis. Several proteins are overexpressed in this cancer type, including the MET tyrosine kinase receptor and the transcription factor PAX6. In this report, we find that PAX6(5a), an alternately spliced variant form of PAX6, is expressed in pancreatic carcinoma cell lines at higher levels than the canonical , protein. Both protein forms of , bind directly to an . . .
  

   

  

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