Pbaf loss leads to dna damage-induced inflammatory signaling through defective g2/m checkpoint maintenance

HIGHLIGHTS

• who: DNA damage from the The Institute University of United Kingdom have published the Article: PBAF loss leads to DNA damage-induced inflammatory signaling through defective G2/M checkpoint maintenance, in the Journal: (JOURNAL)
• what: The authors show that PBRM1 is required for maintaining the G2/M DNA damage checkpoint. Based on the data , the authors propose that PBRM1 loss in renal cancer influences ICI responses at least in part through dysregulation of the p53-dependent DREAM pathway.
• how: The authors investigated whether PBRM1 was working in the same pathway as p53. The . . .
  

   

  

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