HIGHLIGHTS
- who: March et al. from the Shanghai Tong University, China have published the article: PBPK-based dose nding for sildena l in pregnant women for antenatal treatment of congenital diaphragmatic hernia, in the Journal: (JOURNAL)
- what: The aim of this work is to develop a PBPK model to predict the required maternal dose to achieve therapeutic fetal exposure for the treatment of congenital diaphragmatic hernia. To verify the predictive performance of the model, visual predictive checks (VPC) were used to compare the predicted concentration time profiles with observed plasma profiles reported for adult reference individuals . . .
If you want to have access to all the content you need to log in!
Thanks :)
If you don't have an account, you can create one here.