Pbx1-sirt1 positive feedback loop attenuates ros-mediated hf-msc senescence and apoptosis

HIGHLIGHTS

• who: Yuan Wang from the Department of Toxicology, School of Public Health, Jilin University, Xinmin Changchun, Jilin, China have published the paper: PBX1-SIRT1 Positive Feedback Loop Attenuates ROS-Mediated HF-MSC Senescence and Apoptosis, in the Journal: (JOURNAL)
• what: The authors provide a new perspective on the mechanisms underlying stem cell as well as age-related disease prevention and treatment. The authors demonstrated that PBX1 alleviates HFMSCs senescence and apoptosis by reducing ROS-mediated DNA damage through the regulation of the SIRT1-PARP1 axis.
• how: The results showed that overexpression alleviated HF . . .
  

   

  

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