HIGHLIGHTS
SUMMARY
Since adult neurons progressively lose their endogenous cholesterol synthesis capacity and do not contribute anymore to the overall cholesterol synthesis in the brain, the internalization of exogenous cholesterol from other cells, mainly astrocytes, remains their main source of cholesterol supply. Based on these premises, the aim of this study was to evaluate in_vitro the effect of PCSK9 on cholesterol metabolism in astrocytes and neurons, with particular attention to the overall impact on neuron cholesterol supply. Since recent data reported an influence of amyloid-beta (Aβ), the peptide typically accumulating in the brains of AD . . .
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