Pcsk9 inhibition and cholesterol homeostasis in insulin producing β-cells

HIGHLIGHTS

  • who: Gu00fcnter Pu00e4th from the Division of Endocrinology and Diabetology, Department of Medicine II, Medical Center u2013 University of Freiburg, Faculty of Medicine, University of Freiburg, Germany, Hugstetter Str55, Freiburg, Germany have published the research: PCSK9 inhibition and cholesterol homeostasis in insulin producing u03b2-cells, in the Journal: (JOURNAL)
  • how: The authors evaluated the relevant biology of and the effects of its functional loss in rodent knockout models carriers of LDL-lowering gene variants and inhibitor-treated patients.

SUMMARY

    The released N-terminal domain migrates into the nucleus and acts as . . .

     

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