Perforin-2 clockwise hand-over-hand pre-pore to pore transition mechanism

HIGHLIGHTS

• who: Fang Jiao from the (UNIVERSITY) have published the Article: Perforin-2 clockwise hand-over-hand pre-pore to pore transition mechanism, in the Journal: (JOURNAL) of 23/03/2022
• what: This analysis showed that the MACPF, TMH1, TMH2 and EGF domains formed a robust core, with low RMSDs and rather insensitive to the change of pH, independent of the CCW or CW setting. The authors propose that the transition from pre-pore-I to pre-pore-II corresponds to the MACPF domain flip (Fig 5c). The authors report two unique achievements using HS-AFM . . .
  

   

  

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