Periarteriolar spaces modulate cerebrospinal fluid transport into brain and demonstrate altered morphology in aging and alzheimer⠒s disease

HIGHLIGHTS

• who: Humberto Mestre from the Center forUniversity of Medical Center, Rochester, NY, USA have published the paper: Periarteriolar spaces modulate cerebrospinal fluid transport into brain and demonstrate altered morphology in aging and Alzheimeru2812s disease, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors show that small cisternal tracer readily crosses the pial layers to enter PVS and induces macrophagic responses that correlate with the density of the pial ensheathments. The authors report attenuation of pia in PVS of old mice but expansion in agematched APP/PS1 animals, a mouse model of Alzheimer`s disease . . .
  

   

  

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