Perinatal exposure to the fungicide ketoconazole alters hypothalamic control of puberty in female rats

HIGHLIGHTS

  • who: TYPE et al. from the Centre National de la Recherche (CNRS), France Auburn University, United States have published the paper: Perinatal exposure to the fungicide ketoconazole alters hypothalamic control of puberty in female rats, in the Journal: (JOURNAL)
  • what: Because hypothalamic activity is very sensitive to sex steroids, the authors aimed at determining whether and how EDCs with different mode of action can alter the hypothalamic transcriptome and GnRH release in female rats. The authors investigate the brain from the same animal litters to explore hypothalamic mechanisms potentially involved in the disruption of puberty . . .

     

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