HIGHLIGHTS
- who: Md Tariqul Haque Tuhin from the Long School University of have published the article: Peripherally restricted transthyretin-based delivery system for probes and therapeutics avoiding opioid-related side effects, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: The authors show here that current PAMORAs are poor pharmacological probes that are not suitable for performing accurate in_vivo experiments. The authors show that by conjugating the opioid antagonist naloxone to a hydrophilic derivative of AG10, the authors generate the most potent and peripherally restricted PAMORA (a brief description of the concept of the approach is shown . . .
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