Perk/eif2ak3 integrates endoplasmic reticulum stress-induced apoptosis, oxidative stress and autophagy responses in immortalised retinal pigment epithelial cells

HIGHLIGHTS

• who: Neil Saptarshi from the DepartmentUniversity of have published the research: PERK/EIF2AK3 integrates endoplasmic reticulum stress-induced apoptosis, oxidative stress and autophagy responses in immortalised retinal pigment epithelial cells, in the Journal: Scientific Reports Scientific Reports
• what: The authors propose that following PERK downregulation, the compensatory UPR and cellular antioxidant defence system is impaired. Data generated in this study was analysed to determine statistical significance using the GraphPad Prism 8 (GraphPad Software, USA).
• future: While the authors suggest that the upregulation of apoptosis in AMD RPE is not directly or solely mediated . . .
  

   

  

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