Permeabilization via the p2x7 purinoreceptor reveals the presence of a ca2+-activated cl−conductance in the apical membrane of murine tracheal epithelial cells*

HIGHLIGHTS

• who: Sherif E. Gabriel from the solutionIn contrast, when the mucosal Cl⫺ is partially replaced with iodide or bromide, we observed a smaller UTPinduced secretion and a greater shift from the ideal equilibrium potential, suggesting an ion series for this apical Cl⫺ conductance of Cl⫺ ⬎ I⫺ ⬎ Br⫺ ⬎ gluconate⫺. This anion selectivity sequence is somewhat similar to other reports of Ca2⫹-activated Cl⫺ channels (14, , ) but importantly differs from the selectivity sequence for CFTR (3, , ) or from the CLC superfamily of Cl⫺ channels (44). Cl⫺ channel blockers were investigated to determine a "sensitivity sequence" for the CaCC channel . . .
  

   

  

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