Peroxisome proliferator-activated receptor (ppar)-2 controls adipocyte differentiation and adipose tissue function through the regulation of the activity of the retinoid x receptor/pparγ heterodimer*

HIGHLIGHTS

• who: Pe̕ter Bai from the transcription initiation (48)Consistent with this line of thinking, there is molecular and in vivo evidence that the enzymatic activity of , is necessary for efficient gene transcription, and inhibition of PARP activity impairs the transcription of a number of different genes, including different chemokines and inflammation-related genes (e_g iNOS, TNF␣, ICAM-1, IL-8, MIP-1␣, and IL-12) (40, , ). , specifically occupies the promoter of PPAR␥ target genes, because it bound efficiently to the regulatory sequence, whereas binding to the corresponding coding sequences was strongly decreased. Despite this rather specific . . .
  

   

  

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