Persistent hepatocyte apoptosis promotes tumorigenesis from diethylnitrosamine-transformed hepatocytes through increased oxidative stress, independent of compensatory liver regeneration

HIGHLIGHTS

• who: Yasutoshi Nozaki from the DepartmentOsaka University have published the Article: Persistent hepatocyte apoptosis promotes tumorigenesis from diethylnitrosamine-transformed hepatocytes through increased oxidative stress, independent of compensatory liver regeneration, in the Journal: Scientific Reports Scientific Reports of 30/Oct/2020
• what: The authors demonstrated that persistent hepatocyte apoptosis-induced oxidative stress accelerates tumor formation in livers harboring transformed hepatocytes.

SUMMARY

To clarify the effect of hepatocyte apoptosis on tumor formation, the authors injected diethylnitrosamine (DEN) into two-week-old hepatocyte-specific Mcl-1 knockout mice (Mcl-1Δhep mice), which showed . . .

 



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